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Methoxphenidine (also known as MXP) is a lesser-known novel dissociative substance of the diarylethylamine class that produces dissociative and hallucinogenic effects when administered. It is structurally related to diarylethylamines like diphenidine and ephenidine.

Methoxphenidine is classified as an NMDA receptor antagonist. Members of this class induce a state known as “dissociative anesthesia” and are used in both medical (e.g. surgical anesthesia) and recreational settings. These include arylcyclohexylamines like ketamine and phencyclidine (PCP), as well as dextromethorphan (DXM).

Methoxphenidine along with related diarylethylamines have been studied as treatments for neurotoxic injuries. It has no documented history of non-medical use before the 2013 UK arylcyclohexylamine ban, when it and diphenidine became available in powder and tablet form on the online research chemical market. It was initially marketed as a replacement for methoxetamine (MXE) although users report substantially different effects. It is an example of a designer drug specifically chosen to mimic the functional or structural features of commonly used illicit substances and circumvent government regulation.

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Very little data exists about the pharmacological properties, metabolism, and toxicity of methoxphenidine in humans, and it has an extremely limited history of human usage. A number of fatal and non-fatal overdoses have been linked to the abuse of diarylethylamines. Many reports suggest that they may pose different and more pronounced risks than traditional dissociatives. It is highly advised to use harm reduction practices if using this substance.

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Methoxphenidine, or 2-MeO-Diphenidine is a molecule of the diarylethylamine class. It contains a substituted phenethylamine skeleton with an additional phenyl ring bound to Rα. The terminal amino group of the phenethylamine chain is incorporated into a piperidine ring. Hence, methoxphenidine belongs to the piperidine dissociative class of compounds. Methoxphenidine is structurally analogous to Diphenidine, containing an additional 2-methoxy CH3O- substitution.

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